I would not boost it if it is the first time you're using. At least get to know the rubber first and determine whether you want to boost it or not.
There are some extensive reviews coming out on this rubber (unfortunately for most people it's Japanese). Below is one recently released by WRM. I usually take their reviews with a grain of salt because they tend to exaggerate the strength of a rubber, but in this case it was quite informative. I was also okay because they are comparing R47 with R53, so if anything they are just cannibalizing their own product.
https://youtu.be/_3CHlSzfNVM
The guy in the middle is among the top players in Japan and is an Andro representative.
Overall summary:
1. The rubber feels surprisingly softer than they expected. Despite 6 degree difference, they sound almost the same too. They were surprised by how well the sponge grabbed the ball despite testing it on Kanter which is a relatively stiff Balsa blade. They even felt like "the rubber almost does the job for you".
2. The top sheet is very grippy and it's very easy to lift the ball even when it's dipping below the table. They even said it's easier to lift than using R47, but I would say with a caveat that only if you are an advanced player that can brush the ball.
3. Much easier to generate spin in serves. They feel the rubber bites the ball very well and it spins the ball well while keeping it short. Whereas with R47, due to its bounciness, the ball gets pushed out more without generating the spin. If you go to the section where Xia (the penholder) serves, he was doing some full stroke serve while still making the ball bounce twice on the opponent's side.
Overall, they really make it sound like it's a fairly easy rubber to use. At some point they also said it felt softer than R50, likely due to different sponge technology used for R53.
Below is another review on how well R53 pairs with 5-ply and 7-ply wood blades: Andro Wanokiwami AO and REN.
https://youtu.be/b9_NFWDPlWQ
Overall, they said R53 pairs very well with either blades.
I did end up buying a sheet when it was on sale last week on TT11, thanks to Airoc's and guni4you's enthusiasm and I plan to slap it on my Acoustic to give it a try maybe in a couple of months.
I've always loved using boosted H3 on Acoustic but I stepped away from H3 due to the hassle of boosting. Now I'm using Long 5 with D05 but I can't say I like this set up more than Acoustic + H3. Once my D05 wears out, I'll try Acoustic and R53.