Search results

More less than good news for chloroquine in JAMA. A randomized clinical trial had to be stopped early because of adverse effects.. We still don't know how it will fare in patients with less severe disease. Results Out of a predefined sample size of 440 patients, 81 were enrolled (41 [50.6%]...

A specificity range that wide is going to be a $hit$how for population statistics. That is a huge issue for the Santa Clara study.

Here is a site I like for Covid-19 predictions from Los Alamos National Laboratory. It is quite geeky but it provides useful ranges. https://covid-19.bsvgateway.org

Agree. In advanced cases it's not really the virus killing people anymore. Do you know anything about the antibody testing? Fase negs and false positives?

Amazingly enough I agree with most of this. I'm guessing 80 to 100 thousand deaths, higher if states go through with ill-considered plans (FL, GA, etc.). That's only in what we would call the first wave. My state is bigger than many countries. Houston, Dallas and Austin should not be treated...

This is in response to a thread over at MyTT where one of the notable virus skeptics suggested he wanted to move to Georgia so he could play again. In case there are people here who share similar thoughts, I figured I would post the following considerations here: 1. Odds of being infected by...

I believe I can fly. I believe in miracles. This I believe. I believe in Santa Claus. Reason to believe. I believe to my soul. Daydream believer. Don't stop believin' Do you believe in magic? I'm a believer. When you believe. Nope. A guy just starting at 15 is not going to be a...

Increasing Zn2+ in cells would be potentially useful but we don't have a way to do it. Zinc dynamics in cells turn out to be really complicated. There are the following proteins that carry Zn into cells:ZnT-1, ZnT-5, ZnT-6, ZnT-7, ZnT-9, Zip1, Zip6, Zip7, Zip14, and TRPC6. There are also...

Setting up any new clinical trials of hydroxychloroquine might be difficult now based on existing data. These have to be approved by what in the US are called institutional review boards. IRBs need to ensure that as much as possible research on human subjects will do no harm and that the...

Yes, in fact that was really their only conclusion, even though their data hint that chloroquine could be making things worse. .

Here is another retrospective study from patients in VA hospitals (which are good for this kind of study because of their electronic patient record are convenient for researchers.. Thry found no benefit from oh-chloroquine with or without azithromycin, and patients receiving oh-chloroquine...

No I don't see one. I am however taking a Zn supplement (small dose though). I don't want to be deficient. There is a rationale based on its ability to lessen duration of common colds, which use a somewhat similar replicase but which are most of the time not due to coronaviruses. The only...

I personally await a proper study, one that doesn't have to be retracted by the publishers of the journal. Be careful who you listen to. The biggest proponent of chloroquine and HOCQ once owned a multi-level-marketing company (pyramid scheme) that sold "personalized" vitamin supplements...

There is a precedent and warning from a very well documented previous event. Spanish Flu epidemic in Denver Colorado, 1918. The situation was virtually identical to present and they were hit by a massive second wave that killed as many people as the first wave. Another thing worth mentioning...

Hey Free Bird, this just came out. It suggests that SARS-CoV-2 infects the supporting cells in the olfactory epithelium, and not the ciliated olfactory receptor neurons themselves. Some of those epithelial cells will actually turn into olfactory receptor neurons (which turn over about every 28...

That's extremely interesting Rain. Years ago I worked at a place where literally everybody around me worked on chemical senses, about half on olfaction and about half on taste. I always wondered why they hired me. Later, oddly enough after I moved from that place, I collaborated with a...

Yes the taste part is more surprising. But as Rain says, even though we know the virus binds with high affinity to ACE-2 this absolutely does not exclude that it could bind to some other surface protein that is then internalized. Maybe a pattern-sensing receptor like TolR or RAGE, or maybe a...

As I've said before, I am not personally convinced that Dr. Evil is actually evil and I am even starting to suspect that this is not his real name. Translating his post into everyday English: Hypoxemia with normal compliance is a weird combination compared to what one would expect in a life...

There is a growing body of clinical experience now in the US (but as yet no published studies) especially from New York, suggesting that ventilators are at the least less helpful for this disease than one would expect and may even make things worse unless used at the lowest possible pressures...

Yes. Some guys I know in Houston are part of one of the remdesivir trials. The info from Univ Chicago was not supposed to be leaked. Maybe somebody was trying to manipulate the Gilead stock price?