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Thats is not the part that baffles me. The virus doesnt need to go to the olfactory bulb (in brain) to suppress olfaction. The peripheral sensory elements of olfactory receptor neurons are found in specialized folds of upper respiratory epithelium called turbinates (in your nose). The cells...

Another thing to keep in mind is that when people die of Covid-19 outside of a hospital it usually doesnt get counted. And that happens a lot. The data are just do spotty.

It's hard to tell from what's out there, but possibly some liver damage reflected in elevated blood levels of liver enzymes. That kind of thing is usually reversible. Ive seen statements that other things might have occurred in critically ill patients (for example acute kidney injury, which is...

A little bit of good news on remdesivir from a group at NIH. Only 6 animals per group. But still the data (assuming they are solid) point in the optimistic direction. For what ts worth, in my field (which is not this) the groups at NIH are really strong. This is a model of early stage a d...

Yes, this my understanding too, but I dont know what the standard of care (SOC) group will be either. Hopefully we'll have more definitive news soon.

More on the remdesivir trial that includes the Chicago patients. It will include 2400 patients and will analyze a 7-point ordinal endpoint, which includes the outcomes of death, use of mechanical ventilation or extracorporeal membrane oxygenation, use of high-flow oxygen or noninvasive...

From what I can tell the results of a complete multi-intitutional trial will come soon. But at Univ Chicago Hospital, part of the trial, out of 113 severely ill patients treated with remdesivir, only 2 died and most have been discharged. We dont yet have data from placebo controls, but based...

Maybe a somewhat slower blade or rubber could help a little, I'd need to see you play to know for sure. It depends a bit on the economics of it. If you can easily afford another blade you could try getting something in the OFF category, but only expect small improvement. If the price of blade...

Ok, apparently this is an issue all over the world. ICU specialists are starting to think that Covid-19 does not behave exactly like Acute Respiratory Distress Syndrome, and intubateing patients earlier in the course of the disease (as was recommended originally in China) may be leading to...

No, unfortunately. Immunity to smallpox, influenza, chickenpox, measles, polio, TB, etc.etc. will not make you immune to coronavirus. Previous exposure to some other coronavirus MIGHT help a very little if they have a few similar antigenic sites in the S-proteins. Most people in the world...

One thing, us the increase in Singapore real, or have they just been doing more testing? We dont know for sure if its temperature or even that it has anything to do with the virus as opposed to people's susceptibility. Again, that is an important point. Biochemically the virus is less stable...

The answer to this depends a lot on your training and practice habits. People are always looking for equipment so,utions to raise their level and rarely find them. At best these yield small improvements, usually if previous equipment was very highly inappropriate. Otherwise it is just change...

Even scarier is the size of that second wave. The problem with this particular model is that it depends heavily on accuracy of case rate data, which is not uniformly accurate as it depends on how many people are tested in places at a particular mean maximum temperature. For example, testing in...

I really hope this is true! There are lots if reasons to think it will be. But there are a lot of parameters going on at once. That would certainly be a good thing where I live. Soon it will be a steady furnace (we've already had a few days around 90 F).

One thing about Hong Kong, Singapore and Taiwan is people wear masks. Their outcomes have been better. Here people cant even get them. But it would make me feel more secure personally.

I'll try to do some reading and see if I can at least clarify what the issues are maybe why people disagree. Right now I cant provide any insight at all, u fortunately. I think that pasifid or Dr Evil could weigh in once they can get some time, they would know a lot more than I do about a...

Unfortunately people promoting that idea have no real expertise but have a big megaphone in the media. Right now it just isn't clear yet one way or the other. It seems pretty clear that a lot of people have a hard time dealing with uncertainty, but right now things are uncertain. Zn2+ won't...

I have learned that a retrospective "quasi-randomized" clinical trial will soon appear in the New England Journal of Medicine showing that hydroxychloroquine administration to hospitalized SARS-CoV-2 positive patients for five days was associated with a statistically significant increased need...

Zn inhibits the viral RNA replicase, and may slow the virus a bit if you can get enough uptake into cells. One paper reported that chloroquine enhances Zn uptake in cultured cells, which could occur by preventing the degradation of a Zn transport protein (which the authors didn't consider but...

There are interesting statistics available at the Institute for Health Metrics and Evaluation. They predict the peak in my statec will come in two weeks.